Boron trifluoride etherate → Methyl 4-(mercaptomethyl)-1,3-dithiolane-2-propanoate

HRID 1650259노트

반응식

HRID 1650259 반응식
[SH:1][CH2:2][CH:3]([SH:6])[CH2:4][SH:5].O=[CH:8][CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12].B(F)(F)F.CCOCC>C(Cl)Cl>[SH:1][CH2:2][CH:3]1[CH2:4][S:5][CH:8]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])[S:6]1

참가 물질

5

반응물 3

HCID 8000Boron trifluoride etherateHCID 784951,2,3-PropanetrithiolHCID 83779Methyl 4-oxobutyrate

생성물 1

HCID 14405952Methyl 4-(mercaptomethyl)-1,3-dithiolane-2-propanoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title compound was prepared according to the procedure of Example 1 using 1,2,3-trimercaptopropane (4.21 g, 0.03 mol), methyl 4-oxobutanoate from Example 73 (3.5 g, 0.03 mol) and boron trifluoride etherate (1 ml) in methylene chloride (75 ml). The crude product was chromatographed on silica gel using 5% ethyl acetate/hexane as eluent to give 2.5 g (35%) of product.

후처리

  1. customThe crude product was chromatographed on silica gel using 5% ethyl acetate/hexane as eluent

출처 및 근거

ORD 기록
ord-bcf38bee78c748e2937ac3d15f6b3e59
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04923891

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