Sodium Iodide → HCID 14726173, 화합물

HRID 1650352노트

반응식

HRID 1650352 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10]Cl.[Na+].[I-:14]>CC#N>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10][I:14]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 124777791-(2-Amino-5-chlorophenyl)-2-chloroethan-1-one

생성물 1

HCID 14726173HCID 14726173, 화합물수율 99.2%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 11.208 g (54.93 mM) of 2'-amino-2,5'-di-chloroacetophenone in 281 ml of CH3CN is added 24.7 g (165 mM) of NaI, and the mixture is stirred at room temperature for 2.5 hr. and concentrated under reduced pressure. The residue is dissolved in ethyl acetate, washed with aqueous Na2S2O3, and brine in order, dried and concentrated to give 16.1 g (Yield: 99.2%) of 2'-amino-5'-chloro-2-iodoacetophenone as crystals.

후처리

  1. concentrationand concentrated under reduced pressure
  2. dissolutionThe residue is dissolved in ethyl acetate
  3. washwashed with aqueous Na2S2O3, and brine in order
  4. customdried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-50603343b20340f6b743e3d1ddc51f19
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04923984

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