Sodium Iodide → HCID 19853685, 화합물

HRID 1650354노트

반응식

HRID 1650354 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10]Cl.[Na+].[I-:14]>CC#N>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10][I:14]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 107500971-(2-Amino-5-fluorophenyl)-2-chloroethan-1-one

생성물 1

HCID 19853685HCID 19853685, 화합물수율 85.9%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 23.463 g (125.069 mM) of 2'-amino-2-chloro-5'-fluoroacetophenone in 436 ml of CH3CN is added 56.2 g (375.2 mM) of NaI, and the mixture is stirred at room temperature for 45 min. and concentrated under reduced pressure. The resulting residue is dissolved in ethyl acetate, washed with aqueous Na2S2O3, and brine in order, dried and concentrated to give 29.97 g (Yield: 85.9%) of 2'-amino-5'-fluoro-2-iodoacetophenone as yellow crystals.

후처리

  1. concentrationconcentrated under reduced pressure
  2. dissolutionThe resulting residue is dissolved in ethyl acetate
  3. washwashed with aqueous Na2S2O3, and brine in order
  4. customdried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a9323496a42543e7898a68bee400daa5
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04923984

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