[CH2:1]([C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15](Cl)=[O:16])[CH2:11][CH2:10]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C(Cl)(=O)C(Cl)=O.[F:24][C:25]1[C:30]([F:31])=[C:29]([C:32]#[N:33])[CH:28]=[CH:27][C:26]=1[OH:34].N1C=CC=CC=1>C1(C)C=CC=CC=1.C(Cl)Cl>[CH2:1]([C@H:9]1[CH2:10][CH2:11][C@H:12]([C:15]([O:34][C:26]2[CH:27]=[CH:28][C:29]([C:32]#[N:33])=[C:30]([F:31])[C:25]=2[F:24])=[O:16])[CH2:13][CH2:14]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]A mixture of 0.1 mole of trans-4-octylcyclohexanecarbonyl chloride (prepared from the carboxylic acid with oxalyl chloride in toluene) and 75 ml of methylene dichloride is added to a mixture of 0.1 mole of 2,3-difluoro-4-cyanophenol (prepared as in Example 1), 0.12 mole of pyridine, 10 mmole of 4-N,N-dimethylaminopyridine and 250 ml of methylene dichloride. After being stirred for 10 hours at room temperature, the mixture is washed with dilute hydrochloric acid, saturated sodium bicarbonate solution and water. Working up in the customary manner gives 4-(trans-4-octylcyclohexanecarbonyloxy)-2,3-difluorobenzonitrile.
불러오는 중…
