3,5,5-Trimethyl-2-pyrazoline → 1-(2,6-Dichlorophenylsulphonylcarbamoyl)-3,5,5-trimethyl-2-pyrazoline

HRID 1650989노트

반응식

HRID 1650989 반응식
[CH3:1][C:2]1[CH2:6][C:5]([CH3:8])([CH3:7])[NH:4][N:3]=1.[Cl:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:11]=1[S:17]([N:20]=[C:21]=[O:22])(=[O:19])=[O:18]>O.C1(C)C=CC=CC=1>[Cl:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:11]=1[S:17]([NH:20][C:21]([N:4]1[C:5]([CH3:8])([CH3:7])[CH2:6][C:2]([CH3:1])=[N:3]1)=[O:22])(=[O:18])=[O:19]

참가 물질

5

반응물 2

HCID 2314643,5,5-Trimethyl-2-pyrazolineHCID 128751892,6-Dichlorobenzenesulfonyl isocyanate

생성물 1

HCID 230508981-(2,6-Dichlorophenylsulphonylcarbamoyl)-3,5,5-trimethyl-2-pyrazoline

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

실험 절차

11.2 g of the 3,5,5-trimethyl-2-pyrazoline obtained according to example I(b) are added dropwise while stirring, cooling in cold water and under a nitrogen blanket to a solution of 25.2 g of the 2,6-dichlorobenzenesulphonylisocyanate obtained according to example I(a) in 200 ml of dry toluene. After stirring at room temperature for two hours, the precipitate is sucked off and washed successively with dry toluene and petroleum ether (40-60). The desired 1-(2,6-dichlorophenylsulphonylcarbamoyl)-3,5,5-trimethyl-2-pyrazoline is obtained in a yield of 20.07 g; melting-point 270° C. (decomposition).

후처리

  1. additionare added dropwise
  2. customobtained
  3. stirringAfter stirring at room temperature for two hours
  4. washwashed successively with dry toluene and petroleum ether (40-60)

출처 및 근거

ORD 기록
ord-cf3b4d36ab914790bb87113a3ce05a18
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04927452

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