2-Pyrazoline → 1-(2,6-Difluorophenylsulphonylcarbamoyl)-2-pyrazoline

HRID 1650992

반응식

HRID 1650992 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9]([NH:12][C:13]([NH2:15])=[O:14])(=[O:11])=[O:10].[NH:16]1[CH2:20][CH2:19][CH:18]=N1>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9]([NH:12][C:13]([N:15]1[CH2:18][CH2:19][CH:20]=[N:16]1)=[O:14])(=[O:11])=[O:10]

참가 물질

4

반응물 2

HCID 669622-PyrazolineHCID 53937098N-(2,6-difluorophenylsulphonyl)urea

생성물 1

HCID 230507491-(2,6-Difluorophenylsulphonylcarbamoyl)-2-pyrazoline

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

N-(2,6-difluorophenylsulphonyl)urea in an amount of 2.36 and 1.40 g of 2-pyrazoline in 20 ml of dioxane are refluxed for 4 hours. After evaporation of the solvent at reduced pressure, the remaining solid is dissolved in 20 ml of water. This solution is filtrated and acidified with conc. hydrochloric acid. The precipitate is sucked off, washed with water and dried, yielding the title product, viz. 1-(2,6-difluorophenylsulphonylcarbamoyl)-2-pyrazoline in a yield of 1.87 g; melting point 183° C.

후처리

  1. customAfter evaporation of the solvent at reduced pressure
  2. dissolutionthe remaining solid is dissolved in 20 ml of water
  3. filtrationThis solution is filtrated
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-b18fa86a7df846fa805fdd7829ec0e5a
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04927452

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