Hexane → HCID 14458736, 화합물

HRID 1651035노트

반응식

HRID 1651035 반응식
Cl.[C:2]1([CH3:18])[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][C:9]1[N:14]=[C:13]([C:15]([NH2:17])=[NH:16])[CH:12]=[CH:11][CH:10]=1.C[O-].[Na+].[CH3:22][CH2:23][CH2:24][CH2:25]CC.C(OCC)(=O)C>CO.COC(OC)C(=O)CC>[CH3:25][C:24]1[CH:23]=[CH:22][N:17]=[C:15]([C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([O:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[CH3:18])[N:14]=2)[N:16]=1

참가 물질

7

반응물 4

HCID 8058HexaneHCID 8857Ethyl AcetateHCID 10942334Sodium MethoxideHCID 23051377HCID 23051377, 화합물

생성물 1

HCID 14458736HCID 14458736, 화합물수율 76%

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 2420211,1-dimethoxybutan-2-one용매

실험 절차

To a mixture of 6-o-tolyloxy-2-picoline amidine hydrochloride (3 g) and methanol (100 ml) were added 28% sodium methoxide solution in methanol (3.3 g) and 1,1-dimethoxybutanone (1.9 g). The mixture was heated under refluxing for an hour, and was left to stand at room temperature. The reaction solution was concentrated under reduced pressure, and the residue obtained was subjected to silica gel column chromatography (eluent; n-hexane: ethyl acetate=2:1 in volume) to obtain 4-methyl-2-(6-o-tolyloxy-2-pyridinyl)pyrimidine (2.4 g, yield 76%).

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder refluxing for an hour
  3. waitwas left
  4. customto stand at room temperature
  5. concentrationThe reaction solution was concentrated under reduced pressure
  6. customthe residue obtained

출처 및 근거

ORD 기록
ord-b8b47f47bd9b492ebf1058464026954d
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04927827

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