Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfoxide → 6,6-Diphenylhex-5-enoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | Benzophenone | HCID 3102 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | (4-Carboxybutyl)triphenylphosphonium bromide | HCID 161236 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 6,6-Diphenylhex-5-enoic acid | HCID 4374627 | 75.2% |
반응 단계
The reaction was carried out as in Example 87 using the following reagents: sodium hydride (56% dispersion in oil; 8.6 g), dimethylsulfoxide (100 mL), (4-carboxybutyl)triphenylphosphonium bromide (36.5 g), benzophenone (18.2 g), and tetrahydrofuran (100 mL). The crude product, isolated in the usual manner, was crystallized from hexane to give 16.5 g of 6,6-diphenyl-5-hexenoic acid, mp 111°-112.5° C. Anal. Calculated for C18H18O2 : C, 81.17; H, 6.81. Found: C, 81.39; H, 6.88.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04927838 |
| 출처 데이터셋 | uspto-grants-1990_05 |
| ORD ID | ord-f3444ea693ce4d0e8b82023a7223aecf |
| 출처 메모 | uspto-grants-1990_05 |