Borane → HCID 15097577, 화합물

HRID 1651254노트

반응식

HRID 1651254 반응식
[C:1]([C:6](=[C:11]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=1)[CH2:7][C:8](O)=[O:9])([O:3][CH2:4][CH3:5])=[O:2].B>O1CCCC1>[CH2:4]([O:3][C:1](=[O:2])[C:6]([CH2:7][CH2:8][OH:9])=[C:11]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=1)[CH3:5]

참가 물질

4

반응물 2

HCID 6331BoraneHCID 23051607HCID 23051607, 화합물

생성물 1

HCID 15097577HCID 15097577, 화합물수율 78.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

As described in Example 135, a solution of 3-carboethoxy-4,4-bis(3-methoxyphenyl)-3-butenoic acid (20.5 g) in dry tetrahydrofuran (100 mL) was treated with a solution of 1M borane in tetrahydrofuran (57 mL) and the reaction was stirred at room temperature overnight. After the usual work up, the crude product was purified by HPLC (diethyl etherhexane; 65:35) to provide 15.4 g of 2-hydroxyethyl-3,3-bis(3-methoxyphenyl)-2-propenoic acid ethyl ester, mp 102.5°-103.5° C. Anal. Calcd for C19H20O3 : C, 77.00; H, 6.80 Found: C, 77.12; H, 6.69

후처리

  1. customAfter the usual work up, the crude product was purified by HPLC (diethyl etherhexane; 65:35)

출처 및 근거

ORD 기록
ord-77f40ba2a57a43afb8ea644b4d502ad8
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04927838

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