Ammonium Hydroxide → Methyl 5-sulfamoylthieno[2,3-b]thiophene-2-carboxylate

HRID 1651509노트

반응식

HRID 1651509 반응식
[OH-].[NH4+:2].[CH3:3][O:4][C:5]([C:7]1[S:11][C:10]2[S:12][C:13]([S:15](Cl)(=[O:17])=[O:16])=[CH:14][C:9]=2[CH:8]=1)=[O:6]>CC(C)=O>[CH3:3][O:4][C:5]([C:7]1[S:11][C:10]2[S:12][C:13]([S:15]([NH2:2])(=[O:17])=[O:16])=[CH:14][C:9]=2[CH:8]=1)=[O:6]

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 14700201129949-97-9

생성물 1

HCID 14700202Methyl 5-sulfamoylthieno[2,3-b]thiophene-2-carboxylate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To stirred ammonium hydroxide (150 ml) was added dropwise 5-methoxycarbonylthieno[2,3-b]thiophene-2-sulfonyl chloride (11.58 g. 39.02 mmoles) dissolved in acetone (140 ml). After the addition was complete, the solution was stirred for 30 minutes. The reaction was worked up by evaporating the ammonia and acetone in vacuo. The crystals were collected and dried (9.66 g.) (89%). Recrystallization from nitromethane gave 7.02 g. mp 219°-220° C.

후처리

  1. additionAfter the addition
  2. customby evaporating the ammonia and acetone in vacuo
  3. customThe crystals were collected
  4. customdried (9.66 g.) (89%)
  5. customRecrystallization from nitromethane
  6. customgave 7.02 g

출처 및 근거

ORD 기록
ord-dc46fc38822d48d4af7543855b3a61b2
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04929549

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