1-Propanamine, 3-(2-methoxyethoxy)- → 5-(N-methoxyethoxypropylcarbamoyl)thieno[2,3-b]thiophene-2-sulfonamide

HRID 1651510노트

반응식

HRID 1651510 반응식
CO[C:3]([C:5]1[S:9][C:8]2[S:10][C:11]([S:13]([NH2:16])(=[O:15])=[O:14])=[CH:12][C:7]=2[CH:6]=1)=[O:4].[CH3:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][CH2:24][NH2:25]>CO>[CH3:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][CH2:24][NH:25][C:3]([C:5]1[S:9][C:8]2[S:10][C:11]([S:13]([NH2:16])(=[O:14])=[O:15])=[CH:12][C:7]=2[CH:6]=1)=[O:4]

참가 물질

4

반응물 2

HCID 1085741-Propanamine, 3-(2-methoxyethoxy)-HCID 14700202Methyl 5-sulfamoylthieno[2,3-b]thiophene-2-carboxylate

생성물 1

HCID 147002065-(N-methoxyethoxypropylcarbamoyl)thieno[2,3-b]thiophene-2-sulfonamide수율 64.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5-Methoxycarbonylthieno[2,3-b]thiophene-2-sulfonamide (0.55 g., 2 mmoles) and 3-(methoxyethoxy)propylamine (0.80 g., 6 mmoles) were refluxed in methanol (5 mL) for 96 hours. The solution was cooled and evaporated in vacuo to remove most of the methanol. Ether was added and the resulting product was recrystallized from 1,2-dichloroethane to give 0.49 g of 5-(N-methoxyethoxypropylcarbamoyl)thieno[2,3-b]thiophene-2-sulfonamide, m.p. 154°-155° C.

후처리

  1. temperatureThe solution was cooled
  2. customevaporated in vacuo
  3. customto remove most of the methanol
  4. additionEther was added
  5. customthe resulting product was recrystallized from 1,2-dichloroethane

출처 및 근거

ORD 기록
ord-e735d9f296a140f5a9de6040ffef178b
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04929549

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