Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → 1-Piperidinebutanoic acid, 4-((4-chlorophenyl)-2-pyridinylmethoxy)-, ethyl ester, mono(4-methylbenzenesulfonate)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | rac Bepotastine Ethyl Ester | HCID 3079389 | — |
| 생성물 | 1-Piperidinebutanoic acid, 4-((4-chlorophenyl)-2-pyridinylmethoxy)-, ethyl ester, mono(4-methylbenzenesulfonate) | HCID 3079388 | 91.4% |
반응 단계
5.33 g (12.78 mmol) of the ethyl ester obtained in Example 26 and 2.43 g (12.78 mmol) of p-toluenesulfonic acid were treated in the same procedure as described in Example 2 to give 6.88 g (91%) of ethyl 4-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]butanoate p-toluenesulfonate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04929618 |
| 출처 데이터셋 | uspto-grants-1990_05 |
| ORD ID | ord-4d93dfd2026b4269b89853f5b29f94ef |
| 출처 메모 | uspto-grants-1990_05 |