Dimethylformamide → HCID 14770848, 화합물

HRID 1651580노트

반응식

HRID 1651580 반응식
[NH2:1][CH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]([F:16])=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([F:17])[CH:8]=2)[CH2:3]1.[C:18](Cl)(=O)[C:19](Cl)=[O:20].CN(C)C=O.C(Cl)[Cl:30]>>[C:19]([NH:1][CH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]([F:16])=[CH:14][C:10]([C:11]([Cl:30])=[O:13])=[C:9]([F:17])[CH:8]=2)[CH2:3]1)(=[O:20])[CH3:18]

참가 물질

5

반응물 4

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 14770846HCID 14770846, 화합물

생성물 1

HCID 14770848HCID 14770848, 화합물

실험 절차

A mixture of 14.2 g (50 mmole) of 4-[3-(amino)cyclopentyl]-2,5-difluorobenzoic acid in 200 ml of methylene chloride was treated with 6.4 g (50 mmol) of oxalyl chloride and 0.5 ml of dimethylformamide. The reaction mixture was stirred at room temperature for 18 hours and the solvent removed in vacuo. The residue was triturated with toluene which was also removed in vacuo. The residue was used without further purification.

후처리

  1. customthe solvent removed in vacuo
  2. customThe residue was triturated with toluene which
  3. customwas also removed in vacuo
  4. customThe residue was used without further purification

출처 및 근거

ORD 기록
ord-3d6f2e382b7c4386a165a848e5105a56
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04929613

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