HCID 14770861, 화합물 → HCID 67916341, 화합물

HRID 1651592노트

반응식

HRID 1651592 반응식
C([NH:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[O:28])[C:15]([C:23]([O:25]CC)=[O:24])=[CH:16][N:17]3[CH:20]3[CH2:22][CH2:21]3)=[CH:12][C:11]=2[F:29])[CH2:6]1)(=O)C.[ClH:30].C(O)C>>[ClH:30].[NH2:4][CH:5]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[O:28])[C:15]([C:23]([OH:25])=[O:24])=[CH:16][N:17]3[CH:20]3[CH2:21][CH2:22]3)=[CH:12][C:11]=2[F:29])[CH2:6]1

참가 물질

3

반응물 2

HCID 14770861HCID 14770861, 화합물HCID 21887872Ethanol hydrochloride

생성물 1

HCID 67916341HCID 67916341, 화합물

실험 절차

A mixture of 20.0 g (50 mmol) of 7-[3-(acetylamino) cyclopentyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, ethyl ester was heated in a mixture of 6.0 M hydrochloric acid/ethanol (20 ml/150 ml) at reflux for 8 hours. The solvent was removed in vacuo and the residue slurried in 200 ml of water and filtered. The filtrate was evaporated in vacuo and the residue triturated in ethanol and filtered. The precipitate was washed with ethanol, ether, and dried in vacuo to give 13.6 g of the title compound.

후처리

  1. temperatureat reflux for 8 hours
  2. customThe solvent was removed in vacuo
  3. filtrationfiltered
  4. customThe filtrate was evaporated in vacuo
  5. customthe residue triturated in ethanol
  6. filtrationfiltered
  7. washThe precipitate was washed with ethanol, ether
  8. customdried in vacuo

출처 및 근거

ORD 기록
ord-e93c26385c0f45478f7ca3633c9527e9
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04929613

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