2-Methylbenzylidenemalonic acid → 2-[(2-methylphenyl)methyl]propanedioic Acid
반응식
[CH3:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[CH:4]=[C:5]([C:9]([OH:11])=[O:10])[C:6]([OH:8])=[O:7]>CCOC(C)=O.CCO.[Pd]>[CH3:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[CH2:4][CH:5]([C:9]([OH:11])=[O:10])[C:6]([OH:8])=[O:7]참가 물질
5
실험 절차
Hydrogenate the acid of Step 1 (24.3 g) in EtOAc (600 ml) and EtOH (100 ml) at 60 psi with 5% Pd/C (1.0 g). After 2 hr., filter and concentrate to obtain the title compound as a beige solid, m.p. 132°-5°.
후처리
- filtration, filter
- concentrationconcentrate
출처 및 근거
- ORD 기록
- ord-8493594692ab4cebad87ac581f5d85ed
- 출처 데이터셋
- uspto-grants-1990_05
- 특허 번호
- US04929641
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