2-(2-Methylbenzyl)acrylic acid → 2-Acetylthiomethyl-3-(2-methylphenyl)propionic acid

반응식

[CH3:1][C:2]1[CH:13]=[CH:12][CH:11]=[CH:10][C:3]=1[CH2:4][C:5](=[CH2:9])[C:6]([OH:8])=[O:7].[C:14]([OH:17])(=[S:16])[CH3:15]>>[C:14]([S:16][CH2:9][CH:5]([CH2:4][C:3]1[CH:10]=[CH:11][CH:12]=[CH:13][C:2]=1[CH3:1])[C:6]([OH:8])=[O:7])(=[O:17])[CH3:15]

참가 물질

반응물 2

HCID 104648332-(2-Methylbenzyl)acrylic acid

HCID 178418634HCID 178418634, 화합물

생성물 1

HCID 100607772-Acetylthiomethyl-3-(2-methylphenyl)propionic acid

실험 절차

To the acid from Step 3 (11.4 g, 65 mmol) add thioacetic acid (9.8 g, 129 mmol). After 3 days, concentrate, treat with toluene, and concentrate again to obtain a solid. Recrystallize from CH2Cl2 :hexane to obtain the title compound, m.p. 63°-70°.

후처리

concentrationconcentrate
additiontreat with toluene
concentrationconcentrate again
customto obtain a solid
customRecrystallize from CH2Cl2

출처 및 근거

ORD 기록: ord-f45c7dfaeacb4e59a3e7ec2084fd0a19
출처 데이터셋: uspto-grants-1990_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04929641

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