Water → 2,2-Dichloro-3,3,3-trifluoro-1-(2,6-dichloro-4-nitrophenyl)-1-propanol

HRID 1651777노트

반응식

HRID 1651777 반응식
[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[C:6]([Cl:13])[C:3]=1[CH:4]=[O:5].[C:14]([C:18]([Zn]Cl)([Cl:20])[Cl:19])([F:17])([F:16])[F:15].C(C(Cl)(Cl)Cl)(F)(F)F.O>CN(C=O)C.C1COCC1.[Zn]>[Cl:19][C:18]([Cl:20])([C:14]([F:17])([F:16])[F:15])[CH:4]([C:3]1[C:2]([Cl:1])=[CH:9][C:8]([N+:10]([O-:12])=[O:11])=[CH:7][C:6]=1[Cl:13])[OH:5]

참가 물질

8

반응물 4

HCID 962WaterHCID 96351,1,1-Trichloro-2,2,2-trifluoroethaneHCID 218388352,6-Dichloro-4-nitrobenzaldehydeHCID 178506323HCID 178506323, 화합물

생성물 1

HCID 148485192,2-Dichloro-3,3,3-trifluoro-1-(2,6-dichloro-4-nitrophenyl)-1-propanol

시약·촉매·용매 3

HCID 23994Zinc촉매HCID 6228Dimethylformamide용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

실험 절차

3 g of 2,6-dichloro-4-nitro benzaldehyde were reacted, in 20 ml of anhydrous DMF under a nitrogen atmosphere, with CF3CCl2ZnCl prepared from 5 g of CF3CCl3 and 2.2 g of Zn in 10 ml of THF at 60° C. for 1 hour. The mixture was heated at 50° C. for 2 hours and at the end of the reaction it was poured into acidulated water and extracted repeatedly with ethyl ether.

후처리

  1. additionwas poured
  2. extractionextracted repeatedly with ethyl ether

출처 및 근거

ORD 기록
ord-fc35abf11ea146ab81193325dcbc2db0
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04929772

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