3-Benzyloxy-pyrid-2-ylsulfonamide → 3-Hydroxypyridine-2-sulfonamide

HRID 1653624노트

반응식

HRID 1653624 반응식
C([O:8][C:9]1[C:10]([S:15]([NH2:18])(=[O:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[C:10]([S:15]([NH2:18])(=[O:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=1

참가 물질

4

반응물 1

HCID 199579343-Benzyloxy-pyrid-2-ylsulfonamide

생성물 1

HCID 199579383-Hydroxypyridine-2-sulfonamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 263.7 g of 3-benzyloxy-pyrid-2-ylsulfonamide in 2.5 l of methanol is hydrogenated with the addition of 26 g of 5% Pd/C catalyst. After 23.8 l of hydrogen have been absorbed, the catalyst is filtered off. After evaporation of the methanol, 3-hydroxypyrid-2-ylsulfonamide remains in the form of a crystalline mass. Melting point 162°-164° C.

후처리

  1. customAfter 23.8 l of hydrogen have been absorbed
  2. filtrationthe catalyst is filtered off
  3. customAfter evaporation of the methanol, 3-hydroxypyrid-2-ylsulfonamide

출처 및 근거

ORD 기록
ord-eb95c2fac7874c788366ee6643fedcc4
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05403814

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