Sodium Methoxide → 2-(2,4-Difluorophenyl)-4-(3-trifluoromethylphenyl)-5-meth anesulfonylpyrimidine

HRID 1653883노트

반응식

HRID 1653883 반응식
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:9]N(C)C)=O.Cl.[F:23][C:24]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:25]=1[C:26]([NH2:28])=[NH:27].C[O-].[Na+]>CO>[F:23][C:24]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:25]=1[C:26]1[N:28]=[C:6]([C:5]2[CH:17]=[CH:18][CH:19]=[C:3]([C:2]([F:1])([F:20])[F:21])[CH:4]=2)[C:8]([S:13]([CH3:16])(=[O:14])=[O:15])=[CH:9][N:27]=1

참가 물질

5

반응물 3

HCID 10942334Sodium MethoxideHCID 200809312,4-Difluoro-benzamidine hydrochlorideHCID 541640061-(3-trifluoromethylbenzoyl)-1-methanesulfonyl-2-(N,N-dimethylamino)ethene

생성물 1

HCID 150368532-(2,4-Difluorophenyl)-4-(3-trifluoromethylphenyl)-5-meth anesulfonylpyrimidine수율 77.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

6 g of 1-(3-trifluoromethylbenzoyl)-1-methanesulfonyl-2-(N,N-dimethylamino)ethene and 4.6 g of 2,4-difluorobenzamidine hydrochloride were dissolved in 30 ml of methanol at room temperature and 1.2 g of sodium methoxide was added thereto. The resulting mixture was heated under reflux for an hour. The solvent was distilled away under reduced pressure. The residue was washed with water and then dried to obtain 6 g of 2-(2,4-difluorophenyl)-4-(3-trifluoromethylphenyl)-5-meth anesulfonylpyrimidine (Compound 147).

후처리

  1. temperatureThe resulting mixture was heated
  2. temperatureunder reflux for an hour
  3. distillationThe solvent was distilled away under reduced pressure
  4. washThe residue was washed with water
  5. customdried

출처 및 근거

ORD 기록
ord-5af1a966d7ca4c1585f20d8d497f9b61
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05403948

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