[(4-Iodophenyl)sulfonyl]-2-pyridylamine → 2-Hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]ethenyl]benzoic acid

HRID 1653898노트

반응식

HRID 1653898 반응식
[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([OH:15])=[C:7]([CH:14]=1)[C:8]([O:10]C(C)C)=[O:9])=[CH2:2].I[C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[OH:15][C:6]1[CH:5]=[CH:4][C:3]([CH:1]=[CH:2][C:17]2[CH:18]=[CH:19][C:20]([S:23]([NH:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=3)(=[O:25])=[O:24])=[CH:21][CH:22]=2)=[CH:14][C:7]=1[C:8]([OH:10])=[O:9]

참가 물질

3

반응물 2

HCID 1143526[(4-Iodophenyl)sulfonyl]-2-pyridylamineHCID 19423367Isopropyl 5-ethenyl-2-hydroxybenzoate

생성물 1

HCID 543430162-Hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]ethenyl]benzoic acid수율 40%

실험 절차

Isopropyl 5-ethenyl-2-hydroxybenzoate was reacted with 4-iodo-N-(2-pyridinyl)benzenesulfonamide similarly to the procedure of Example 5c. After the reaction, the solvent was evaporated, toluene was added and the suspension filtered and washed with toluene. After drying on the filter and washing with water the material was hydrolyzed and precipitated similarly to the procedure of Example 3c. Yield 40%.

후처리

  1. customAfter the reaction
  2. customthe solvent was evaporated
  3. additiontoluene was added
  4. filtrationthe suspension filtered
  5. washwashed with toluene
  6. customAfter drying on the
  7. filtrationfilter
  8. washwashing with water the material
  9. customprecipitated similarly to the procedure of Example 3c

출처 및 근거

ORD 기록
ord-bba47e46358c4e698f580bb1a76d12eb
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05403930

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