5-(Difluoromethyl)furan-2-carbaldehyde → 2-Furanmethanol, 5-(difluoromethyl)-alpha-ethynyl-

HRID 1654107노트

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HRID 1654107 반응식
[C:1]([Mg]Br)#[CH:2].[F:5][CH:6]([F:14])[C:7]1[O:11][C:10]([CH:12]=[O:13])=[CH:9][CH:8]=1.P([O-])(O)(O)=O.[Na+]>O1CCCC1>[F:5][CH:6]([F:14])[C:7]1[O:11][C:10]([CH:12]([OH:13])[C:1]#[CH:2])=[CH:9][CH:8]=1

참가 물질

5

반응물 3

HCID 200796385-(Difluoromethyl)furan-2-carbaldehydeHCID 23672064Monosodium phosphateHCID 178418486HCID 178418486, 화합물

생성물 1

HCID 200796722-Furanmethanol, 5-(difluoromethyl)-alpha-ethynyl-

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

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온도
0 °C

실험 절차

43 ml of a 0.5M solution of ethynyl magnesium bromide in tetrahydrofuran were added at 0° C. over one hour to a solution of 2.5 g of the product of Stage A and 30 ml of tetrahydrofuran. The reaction mixture was stirred at 0° C. for 1 hour and then was poured into a saturated aqueous sodium dihydrogenphosphate solution. The 3 g of product were chromatographed on silica by eluting with a 7/3 hexane/ethyl acetate mixture to obtain 2.5 g of the desired product.

후처리

  1. customThe 3 g of product were chromatographed on silica
  2. washby eluting with a 7/3 hexane/ethyl acetate mixture

출처 및 근거

ORD 기록
ord-9687eb84b4484ce5bb90b631d8726245
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05405865

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