Water → 2-Bromo-1-(2,4-difluorophenyl)propan-1-one

HRID 1654180

반응식

HRID 1654180 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10][CH3:11].[Br:13]Br.O>C(Cl)Cl>[Br:13][CH:10]([CH3:11])[C:9]([C:3]1[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[F:1])=[O:12]

참가 물질

5

반응물 3

HCID 962WaterHCID 24408BromineHCID 1235862',4'-Difluoropropiophenone

생성물 1

HCID 110758302-Bromo-1-(2,4-difluorophenyl)propan-1-one수율 98.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In methylene chloride (300 ml) was dissolved 2',4'-difluoropropiophenone (55 g), to which was added bromine (50 g) dropwise, while stirring, during 30 minutes. The mixture was stirred for 30 minutes at room temperature. To the reaction mixture was added water (200 ml), and the methylene chloride layer was washed three times, followed by drying over anhydrous magnesium sulfate. The solvent was distilled off to leave 2-bromo-2',4'-difluoropropiophenone (77 g) as a pale yellow oily product.

후처리

  1. stirringThe mixture was stirred for 30 minutes at room temperature
  2. washthe methylene chloride layer was washed three times
  3. dry with materialby drying over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-7b5b9527b2b84a238e79ed329f9e217c
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05405861

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