2-Chlorobenzimidazole → N-(Benzimidazol-2-yl)-2,2-bis(4-fluorophenyl)ethylamine

HRID 16543

반응식

HRID 16543 반응식
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[F:11][C:12]1[CH:17]=[CH:16][C:15]([CH:18]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[CH2:19][NH2:20])=[CH:14][CH:13]=1>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:20][CH2:19][CH:18]([C:15]1[CH:16]=[CH:17][C:12]([F:11])=[CH:13][CH:14]=1)[C:21]1[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=1

참가 물질

3

반응물 2

HCID 785722-ChlorobenzimidazoleHCID 8197612,2-Bis(4-fluorophenyl)ethanamine

생성물 1

HCID 11552019N-(Benzimidazol-2-yl)-2,2-bis(4-fluorophenyl)ethylamine

실험 절차

The title compound was prepared from 2-chlorobenzimidazole and 2,2-bis(4-fluorophenyl)ethylamine (prepared by Procedure B from 2,2-bis(4-fluoro-phenyl)acetaldehyde) by Procedure A (20 min at 170° C.). The product was isolated by preparative LCMS to give the title compound as the free base (white solid, mp 155-157° C.). MS(ES+) m/z 350 ([M+1]+, 100) 1NMR (DMSO-d6) δ 3.90 (m, 2H), 4.46 (t, 1H), 6.50 (m, 1H), 6.80-6.90 (m, 2H), 7.07-7.18 (m, 6H), 7.35-7.42 (m, 4H), 10.5 (s, 1H).

후처리

  1. customThe product was isolated by preparative LCMS

출처 및 근거

ORD 기록
ord-d4650308ee104cf59a72eb3ca6abb17b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737167B2

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