2-Chlorobenzimidazole → N-(Benzimidazol-2-yl)-2,2-bis(4-chlorophenyl)ethylamine

HRID 16544

반응식

Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH:18]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)[CH2:19][NH2:20])=[CH:14][CH:13]=1>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:20][CH2:19][CH:18]([C:15]1[CH:16]=[CH:17][C:12]([Cl:11])=[CH:13][CH:14]=1)[C:21]1[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=1

참가 물질

반응물 2

HCID 785722-Chlorobenzimidazole

HCID 131104422,2-Bis(4-chlorophenyl)ethanamine

생성물 1

HCID 11538181N-(Benzimidazol-2-yl)-2,2-bis(4-chlorophenyl)ethylamine

실험 절차

The title compound was prepared from 2-chlorobenzimidazole and 2,2-bis(4-chlorophenyl)ethylamine (prepared by Procedure B from 2,2-bis(4-chloro-phenyl)acetaldehyde) by Procedure A (20 min at 170° C.). The product was isolated by preparative LCMS to give the title compound as the free base (white solid, mp 189-190° C.). MS(ES+) m/z 382 ([M+1]+, 100). 1NMR (DMSO-d6) δ 3.91 (m, 2H), 4.47 (t, 1H), 6.52 (m, 1H), 6.81-6.90 (m, 2H), 7.06-7.18 (m, 2H), 7.33-7.36 (m, 8H), 10.6 (s, 1 H).

후처리

customThe product was isolated by preparative LCMS

출처 및 근거

ORD 기록: ord-cb90506abb62481699de42a7252ee56c
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07737167B2

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