2-Chlorobenzimidazole → (1H-Benzoimidazol-2-yl)indan-1-ylamine

HRID 16546

반응식

HRID 16546 반응식
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH2:11][CH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13]1>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:11][CH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13]1

참가 물질

3

반응물 2

HCID 785722-ChlorobenzimidazoleHCID 123445(+-)-1-Aminoindan

생성물 1

HCID 11550553(1H-Benzoimidazol-2-yl)indan-1-ylamine

실험 절차

The title compound was prepared from 2-chlorobenzimidazole and racemic 1-aminoindane by Procedure A (15 min at 200° C.). The product was isolated by preparative LCMS to give the title compound as the free base and as a mixture of enantiomers (white solid, mp 195.5-197° C.). MS(ES+) m/z 250 ([M+1]+, 100). 1NMR (DMSO-d6) δ 1.90 (m, 1 H), 2.55 (m, 1 H), 2.83 (m, 1 H), 2.95 (m, 1 H), 5.36 (m, 1 H), 6.82-6.97 (m, 3H), 7.11-7.31 (m, 6H), 10.70 (s, 1H).

후처리

  1. customThe product was isolated by preparative LCMS

출처 및 근거

ORD 기록
ord-0286d6bc0d514964b3e0f0f87c14b814
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737167B2

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