2-Aminoindane → (1H-Benzoimidazol-2-yl)indan-2-ylamine

HRID 16547

반응식

HRID 16547 반응식
Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH2:11][CH:12]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13]1>>[N:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[NH:3][C:2]=1[NH:11][CH:12]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13]1

참가 물질

3

반응물 2

HCID 763102-AminoindaneHCID 785722-Chlorobenzimidazole

생성물 1

HCID 11658857(1H-Benzoimidazol-2-yl)indan-2-ylamine

실험 절차

The title compound was prepared from 2-chlorobenzimidazole and 2-aminoindane by Procedure A (15 min at 150° C.). The product was isolated by preparative LCMS to give the title compound as the free base (white solid, mp 246-249° C.). MS(ES+) m/z 250 ([M+1]+, 100). 1NMR (DMSO-d6) δ 2.91 (dd, 2H), 3.29 (dd, 2H), 4.35 (m, 1H), 6.80-6.92 (m, 3H), 7.10-7.17 (m, 4H), 7.22-7.25 (m, 2H), 10.60 (s, 1H).

후처리

  1. customThe product was isolated by preparative LCMS

출처 및 근거

ORD 기록
ord-94593ddfd76d49909c5e0097ba1ae034
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737167B2

연결된 노트

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