Toluene → N-(3-(4-Methoxybenzyloxy)pyrid-2-yl)-N'-(4-chlorophenyl)thiourea

HRID 1654882노트

반응식

HRID 1654882 반응식
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]=[C:26]=[S:27])=[CH:21][CH:20]=1.C1(C)C=CC=CC=1>C(OCC)C>[CH3:17][O:16][C:13]1[CH:14]=[CH:15][C:10]([CH2:9][O:8][C:7]2[C:2]([NH:1][C:26]([NH:25][C:22]3[CH:23]=[CH:24][C:19]([Cl:18])=[CH:20][CH:21]=3)=[S:27])=[N:3][CH:4]=[CH:5][CH:6]=2)=[CH:11][CH:12]=1

참가 물질

5

반응물 3

HCID 1140TolueneHCID 164804-Chlorophenyl isothiocyanateHCID 27283893-[(4-Methoxybenzyl)oxy]pyridin-2-amine

생성물 1

HCID 20076976N-(3-(4-Methoxybenzyloxy)pyrid-2-yl)-N'-(4-chlorophenyl)thiourea

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 2-amino-3-(4-methoxybenzyloxy)pyridine (1.80 g, 0.0078 mol), 4chlorophenyl isothiocyanate (1.58 g, 0.0094 mol) and toluene (10 ml) was refluxed for 3.5 hours, then cooled and treated with diethyl ether to induce crystallisation of the product. Yield 2.2 g (70.5%), m.p. 136°-138 ° C.

후처리

  1. temperaturewas refluxed for 3.5 hours
  2. temperaturecooled
  3. customcrystallisation of the product

출처 및 근거

ORD 기록
ord-1db6ed41fc37437e83c0fec0424c0677
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409943

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