Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 2-Amino-3-(2,4,6-trifluorobenzyloxy)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-Amino-3-Hydroxypyridine | HCID 28114 | — |
| 반응물 | 2,4,6-Trifluorobenzyl bromide | HCID 2777059 | — |
| 촉매 | Trioctylmethylammonium chloride | HCID 21218 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Amino-3-(2,4,6-trifluorobenzyloxy)pyridine | HCID 10015161 | — |
반응 단계
A mixture of 2-amino-3-hydroxy pyridine (2.44 g, 0.022 mol), dichloromethane (20 ml) and 40% aqueous sodium hydroxide solution (20 ml) was stirred for five minutes, then 2,4,6-trifluorobenzyl bromide (5.00 g, 0.022 mol) and Adogen 464 (3 ml) were added and stirring continued for 16 hours. The mixture was diluted with water and extracted with dichloromethane. Drying and evaporation of the organic extracts, and trituration with ether gave the desired product. Yield 2.76 g (49%), m.p. 122°-124 ° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05409943 |
| 출처 데이터셋 | uspto-grants-1995_04 |
| ORD ID | ord-bb33cbd7b8a34d758b52d28e57911d25 |
| 출처 메모 | uspto-grants-1995_04 |