Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → 3-(2,4,6-Trifluorobenzyloxy)pyrid-2-yl-N'-(4-chlorophenyl)thiourea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | 4-Chlorophenyl isothiocyanate | HCID 16480 | — |
| 반응물 | 2-Amino-3-(2,4,6-trifluorobenzyloxy)pyridine | HCID 10015161 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 3-(2,4,6-Trifluorobenzyloxy)pyrid-2-yl-N'-(4-chlorophenyl)thiourea | HCID 20077009 | — |
반응 단계
A mixture of 2-amino-3-(2,4,6-trifluorobenzyloxy)pyridine (2.29 g, 0.009 mol), 4chlorophenyl isothiocyanate (1.81 g, 0.01 mol) and toluene (10 ml) was refluxed for 3.5 hours, then cooled and treated with diethyl ether to induce crystallisation of the product. Yield 3.03 g (79.5%), m.p.181°-183 ° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05409943 |
| 출처 데이터셋 | uspto-grants-1995_04 |
| ORD ID | ord-2c38946663564af9b9e2c72d913ca0cc |
| 출처 메모 | uspto-grants-1995_04 |