Ammonia → HCID 178512030, 화합물

HRID 1654929노트

반응식

HRID 1654929 반응식
[Cl:1][C:2]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:13][C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=S)=[N:8][CH:9]=[C:10]([Cl:12])[CH:11]=1.[NH3:29]>>[Cl:1][C:2]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:3]=1[CH2:4][O:5][C:6]1[C:7]([NH:13][C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[NH:29])=[N:8][CH:9]=[C:10]([Cl:12])[CH:11]=1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 20076938HCID 20076938, 화합물

생성물 1

HCID 178512030HCID 178512030, 화합물

실험 절차

A mixture of yellow men:uric oxide (0.36 g, 0.0017 mol), N-[3-(2-chloro-6-fluorobenzyloxy)-5-chloropyrid-2-yl]-N'-4-chlorophenylthiourea (0.64 g, 0.0014 mol)and methanolic ammonia solution (20 ml) was stirred for 1 day at room temperature. The solvent was removed in vacuo and the black residue was boiled with chloroform and filtered hot. Evaporation of the solvent followed by recrystallisation from ethanol gave the desired product. Yield 0.09 g (15%), m.p. 162°-163 ° C.

후처리

  1. additionA mixture of yellow men
  2. customThe solvent was removed in vacuo
  3. filtrationfiltered hot
  4. customEvaporation of the solvent
  5. customfollowed by recrystallisation from ethanol

출처 및 근거

ORD 기록
ord-3507b44652704b43a0079b336444d124
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409943

반응 노트

불러오는 중…