Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 2-Amino-3-(2-chloro-6-fluorobenzyloxy)-6-methylpyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-Amino-6-methylpyridin-3-ol | HCID 88500 | — |
| 반응물 | 1-Chloro-2-(chloromethyl)-3-fluorobenzene | HCID 108675 | — |
| 촉매 | Trioctylmethylammonium chloride | HCID 21218 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Amino-3-(2-chloro-6-fluorobenzyloxy)-6-methylpyridine | HCID 20076974 | — |
반응 단계
A mixture of 2-amino-3-hydroxy-6-methylpyridine (4.3 g, 0.035 mol), dichloromethane (26 ml) and 40% aqueous sodium hydroxide solution (26 ml) was stirred for five minutes at room temperature, then 2-chloro-6-fluorobenzyl chloride (6.8 g, 0.038 mol) and Adogen 464 (2.5 ml) were added and stirring continued for 16 hours. The mixture was diluted with water and extracted with dichloromethane. Drying and evaporation of the organic extracts and trituration with ethanol gave the desired product. Yield 6.3 g (67%), m.p. 108°-109 ° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05409943 |
| 출처 데이터셋 | uspto-grants-1995_04 |
| ORD ID | ord-c73661605cef49ffab5025d851406823 |
| 출처 메모 | uspto-grants-1995_04 |