m-Chloroperbenzoic acid → HCID 20077200, 화합물

HRID 1654952노트

반응식

HRID 1654952 반응식
[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10](C(=O)C)[CH:11]=2)[CH2:6]1.ClC1C=CC=[C:21]([C:25]([O:27]O)=[O:26])C=1>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:27][C:25](=[O:26])[CH3:21])[CH:11]=2)[CH2:6]1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 20077196HCID 20077196, 화합물

생성물 1

HCID 20077200HCID 20077200, 화합물수율 97%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

11.0 g (47.0 mmol) of methyl(5-acetylindan-2-yl)acetate was dissolved in 200 ml of methylene chloride, to which was added 14.6 g (67 mmol) of m-chloroperbenzoic acid and stirred for 4 hours at room temperature, followed by refluxing for 17 hours. The reaction mixture was washed with saturated aqueous sodium bicarbonate and water in this order, dried and then the solvent was removed. The residue was purified by silica gel column chromatography (chloroform) to obtain 11.3 g of an oily product. Yield: 97%

후처리

  1. temperatureby refluxing for 17 hours
  2. washThe reaction mixture was washed with saturated aqueous sodium bicarbonate and water in this order
  3. customdried
  4. customthe solvent was removed
  5. customThe residue was purified by silica gel column chromatography (chloroform)

출처 및 근거

ORD 기록
ord-fb7ee56e50bc459fa4fa577f5c76189a
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05409956

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