5,6-Bis(phenylmethoxy)-1H-indole → 5,6-Dihydroxyindole

HRID 1655030노트

반응식

HRID 1655030 반응식
C([O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[O:14]C(=O)C)[NH:10][CH:9]=[CH:8]2)(=O)C.C(OC1C=C2C(=CC=1OCC1C=CC=CC=1)NC=C2)C1C=CC=CC=1>[Fe].C(O)(=O)C>[OH:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[OH:14])[NH:10][CH:9]=[CH:8]2

참가 물질

5

반응물 2

HCID 209205,6-Bis(phenylmethoxy)-1H-indole2회HCID 38058835,6-Diacetoxyindole

생성물 1

HCID 1146835,6-Dihydroxyindole

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

실험 절차

In a first stage, 5,6-diacetoxyindole and 5,6-dibenzyloxyindole are prepared by means of a cyclizing reduction. In the case of 5,6-dibenzyloxyindole the cyclizing reduction is carried out using iron in the presence of acetic acid. In a second stage, 5,6-dihydroxyindole is obtained:

출처 및 근거

ORD 기록
ord-439111d22b684e2e8c5ea4b43c29f935
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05410067

반응 노트

불러오는 중…