Nitric Acid → 4-(Methylsulfanyl)-2-nitrophenol
반응식
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[N+:10]([O-])([OH:12])=[O:11]>C(Cl)Cl>[N+:10]([C:7]1[CH:8]=[C:3]([S:2][CH3:1])[CH:4]=[CH:5][C:6]=1[OH:9])([O-:12])=[O:11]참가 물질
4
실험 절차
To a solution of 4-(methylthio)phenol(5.0 g) in methylene chloride (100 mls) was added 30% nitric acid absorbed on silica (9.29 g) and the mixture stirred at room temperature for 3hrs. The mixture was filtered and washed with methylene chloride. The solvent was evaporated and the residue was purified by flash chromatography eluting with ethyl acetate and hexane (15:85 v/v ) to give 2-nitro-4-(methylthio)phenol as an orange solid (2.22 g);
후처리
- customabsorbed on silica (9.29 g)
- filtrationThe mixture was filtered
- washwashed with methylene chloride
- customThe solvent was evaporated
- customthe residue was purified by flash chromatography
- washeluting with ethyl acetate and hexane (15:85 v/v )
출처 및 근거
- ORD 기록
- ord-81bed632dbd54875956ae110e783d8c1
- 출처 데이터셋
- uspto-grants-1995_04
- 특허 번호
- US05410064
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