Ethyl chloroformate → HCID 19933000, 화합물

반응식

[C:1](O)(=O)[C:2]([OH:4])=[O:3].[CH2:7]([C:10]1[N:23]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]3C=[CH:35][CH:34]=[CH:33][CH:32]=3)=[C:27](C(OC(C)(C)C)=O)[CH:26]=2)[C:13]2[CH:14]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[NH:15][CH2:16][CH2:17][C:12]=2[N:11]=1)[CH2:8][CH3:9].Cl[C:45]([O:47][CH2:48][CH3:49])=[O:46]>>[CH2:7]([C:10]1[N:23]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][C:1]=3[C:2]([O:4][C:25]([CH3:30])([CH3:26])[CH3:24])=[O:3])=[CH:27][CH:26]=2)[C:13]2[CH:14]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[N:15]([C:45]([O:47][CH2:48][CH3:49])=[O:46])[CH2:16][CH2:17][C:12]=2[N:11]=1)[CH2:8][CH3:9]

참가 물질

반응물 2

HCID 10928Ethyl chloroformate

HCID 20076809HCID 20076809, 화합물

생성물 1

HCID 19933000HCID 19933000, 화합물수율 169.1%

실험 절차

The compound obtained in Example 62 (1.00 g) is treated in the same manner as in Example 64 with using ethyl chloroformate (0.27 g) instead of acetic anhydride to give ethyl 2-n-propyl-5-ethoxycarbonyl-3-[2'-(t-butoxycarbonyl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]-pyridine-4-carboxylate (0.82 g) as a white foam.

출처 및 근거

ORD 기록: ord-52090f0e767e410195c721b3c2ff683f
출처 데이터셋: uspto-grants-1995_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05409936

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