Thionyl Chloride → HCID 131718192, 화합물

HRID 1655190노트

반응식

HRID 1655190 반응식
[C:1]([C:3]1[CH:4]=[N:5][N:6]([C:13]2[C:18]([Cl:19])=[CH:17][C:16]([C:20]([F:23])([F:22])[F:21])=[CH:15][C:14]=2[Cl:24])[C:7]=1[CH:8]=[CH:9][C:10](O)=[O:11])#[N:2].S(Cl)([Cl:27])=O>C1(C)C=CC=CC=1>[C:1]([C:3]1[CH:4]=[N:5][N:6]([C:13]2[C:18]([Cl:19])=[CH:17][C:16]([C:20]([F:23])([F:21])[F:22])=[CH:15][C:14]=2[Cl:24])[C:7]=1[CH:8]=[CH:9][C:10]([Cl:27])=[O:11])#[N:2]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 67858667HCID 67858667, 화합물

생성물 1

HCID 131718192HCID 131718192, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

By the method of Example 7, Step A, 0.96 g (0.0026 mole) of 3-[4-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazol-5-yl]acrylic acid and 1 mL of thionyl chloride were reacted in 20-30 mL of toluene, yielding 0.56 g of 3-[4-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazol-5-yl]acrylic acid chloride as an oil. The nmr spectrum was consistent with the proposed structure and indicated the product to be primarily the trans acrylic acid derivative.

출처 및 근거

ORD 기록
ord-960a30c824454ff288f7e356804bdbe1
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05250504

반응 노트

불러오는 중…