Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-alpha-t-Butyloxycarbonyl-L-biphenylalanine (Boc-L-Bip-OH)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Methyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoate | HCID 2736832 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | N-alpha-t-Butyloxycarbonyl-L-biphenylalanine (Boc-L-Bip-OH) | HCID 2761796 | — |
반응 단계
(S)-2-(t-butoxycarbonylamino-3-(biphenyl-4-yl)-propionic acid methyl ester (4.1 g, 11.5 mmol) is dissolved at room temperature in methanolic 1N sodium hydroxide (60 mL). The solution is stirred for 3 hours. Ether (30 mL) and water (30 mL) are added. The aqueous layer is separated and acidified with concentrated hydrochloric acid, then extracted with ether (2×20 mL) and dried over anhydrous sodium sulfate. Evaporation of the solvent under reduced pressure gives (S)-2-(t-butoxycarbonylamino)-3-(biphenyl-4-yl)-propionic acid as a white solid, m.p. 122°-123°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05250522 |
| 출처 데이터셋 | uspto-grants-1993_10 |
| ORD ID | ord-db66ccf862ca4008bdc7f35329cba1e5 |
| 출처 메모 | uspto-grants-1993_10 |