Acrylonitrile → 1-(4-Benzyloxy benzoyl) 2-(2-cyano ethyl) hydrazine

HRID 1655357노트

반응식

HRID 1655357 반응식
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([NH:15][NH2:16])=[O:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19](#[N:22])[CH:20]=[CH2:21]>C(O)CC>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([NH:15][NH:16][CH2:21][CH2:20][C:19]#[N:22])=[O:14])=[CH:17][CH:18]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 7855Acrylonitrile2회HCID 15264864-(Benzyloxy)benzohydrazide

생성물 1

HCID 110984481-(4-Benzyloxy benzoyl) 2-(2-cyano ethyl) hydrazine수율 88%

시약·촉매·용매 1

HCID 10311-Propanol용매

실험 절차

To a solution of 100 mmoles of (4-benzyloxy benzoyl) hydrazine in 200 ml of 1-propanol, 100 mmoles of acrylonitrile are added and the mixture is heated for 24 hours at reflux. Then 50 mmoles of acrylonitrile are added and the heating is continued at reflux for 24 hours. After cooling, the product is filtered and recrystallized in a water-ethanol mixture and 26 g (yield: 88%) of the expected product were obtained.

후처리

  1. temperaturethe mixture is heated for 24 hours
  2. temperatureat reflux
  3. temperatureat reflux for 24 hours
  4. temperatureAfter cooling
  5. filtrationthe product is filtered
  6. customrecrystallized in a water-ethanol mixture

출처 및 근거

ORD 기록
ord-1359b3e2a3d54ce39397bf101b45e1cf
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05250551

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