Triethylamine → HCID 19792116, 화합물

HRID 1655464노트

반응식

HRID 1655464 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C(N(CC)CC)C.[C:20](Cl)(=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24]>C(Cl)Cl>[Cl:12][C:9]1[CH:10]=[CH:11][C:2]([NH:1][C:20](=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24])=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 78878Methyl 2-amino-5-chlorobenzoate

생성물 1

HCID 19792116HCID 19792116, 화합물수율 61%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of methyl 2-amino-5-chlorobenzoate (15 g) and triethylamine (12 ml) in methylene chloride (150 ml) was added dropwise, while stirring under ice-cooling, valeryl chloride (10 ml). The mixture was stirred at room temperature for further two hours. The reaction mixture was washed with an aqueous solution of sodium bicarbonate and water, followed by drying. The solvent was distilled off to afford a pale yellow crystals (13.4 g, 61%), m.p. 48-49° C.

후처리

  1. temperaturecooling
  2. stirringThe mixture was stirred at room temperature for further two hours
  3. washThe reaction mixture was washed with an aqueous solution of sodium bicarbonate and water
  4. customby drying
  5. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-04ad8f63b43543d79bcc5df67637cbab
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05250554

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