Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → Ethyl 2-cyano-3-phenylpropanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Ethyl cyanoacetate | HCID 7764 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 2-cyano-3-phenylpropanoate | HCID 228103 | — |
반응 단계
Cyanoacetic acid ethyl ester was alkylated with benzyl bromide in the presence of sodium ethylate in ethanol to give benzyl-cyanoacetic acid ethyl ester [MS: 203 (M)+ ] which was then subsequently hydrolyzed with 1N sodium hydroxide solution in a 9:1 mixture of methanol and water to give the corresponding acid. Recrystallization of the crude product from methylene chloride/hexane yielded benzyl-cyanoacetic acid as crystals of melting point 97°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05250517 |
| 출처 데이터셋 | uspto-grants-1993_10 |
| ORD ID | ord-281acf31a33a48f3889494a81c311132 |
| 출처 메모 | uspto-grants-1993_10 |