Dicyclohexylcarbodiimide → 2,4-Dimethyl-4-isopropyl-2-oxazolin-5-one

HRID 1655844노트

반응식

HRID 1655844 반응식
[C:1]([NH:4][C:5]([CH3:12])([CH:9]([CH3:11])[CH3:10])[C:6]([OH:8])=[O:7])(=O)[CH3:2].C1(N=C=NC2CCCCC2)CCCCC1>C1COCC1>[CH3:2][C:1]1[O:7][C:6](=[O:8])[C:5]([CH3:12])([CH:9]([CH3:11])[CH3:10])[N:4]=1

참가 물질

4

반응물 2

HCID 10868DicyclohexylcarbodiimideHCID 2338052-Acetamido-2,3-dimethylbutanoic acid

생성물 1

HCID 146957652,4-Dimethyl-4-isopropyl-2-oxazolin-5-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
25 °C

실험 절차

2-Acetamido-2,3-dimethylbutyric acid (16 g) is dissolved in THF (200 mL) and dicyclohexylcarbodiimide (DCC, 21.0 g) is added. The mixture is allowed to stir for 16 hours at 25° C. At the end of this time the mixture is filtered and evaporated to dryness. The residue is dissolved in CH2Cl2 (10 mL) and filtered again. Evaporation of the filtrate gives the crude product which is purified by distillation at 0.65 mmHg, having bp 50° C.

후처리

  1. filtrationAt the end of this time the mixture is filtered
  2. customevaporated to dryness
  3. dissolutionThe residue is dissolved in CH2Cl2 (10 mL)
  4. filtrationfiltered again
  5. customEvaporation of the filtrate

출처 및 근거

ORD 기록
ord-38b800039dcc41c89b118753c3ec2882
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05252539

반응 노트

불러오는 중…