Methanesulfonyl chloride → 1-Propanol, 3-(trimethylsilyl)-

HRID 1655989노트

반응식

HRID 1655989 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH3:6][Si:7]([CH3:13])([CH3:12])[CH2:8][CH2:9][CH2:10][OH:11]>ClCCl>[CH3:6][Si:7]([CH3:13])([CH3:12])[CH2:8][CH2:9][CH2:10][OH:11].[CH3:1][S:2]([O-:4])(=[O:11])=[O:3]

참가 물질

5

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 762131-Propanol, 3-(trimethylsilyl)-

생성물 2

HCID 762131-Propanol, 3-(trimethylsilyl)-HCID 85257Methanesulfonate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Methanesulfonylchloride (0.73 ml, 9 mmol) was added dropwise to a solution of 3-(trimethylsilyl)-1-propanol (1.2 ml, 7.56 mmol) cooled at 0° C. in 20 ml of dichloromethane. After 45 minutes stirring, the reaction mixture was partitioned between water and dichloromethane, the organic phase was separated, the solvent was evaporated under reduced pressure to afford the expected 3-(trimethylsilyl)-1-propanol, methanesulfonate in crude quantitative yield.

후처리

  1. customthe reaction mixture was partitioned between water and dichloromethane
  2. customthe organic phase was separated
  3. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-7b4c312d11d74f4395c712f71157cdbd
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05252587

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