(Dimethyl sulfide)trihydroboron → 4-(Trimethylsilyl)butan-1-ol
반응식
CSC.B.[CH3:5][Si:6]([CH3:14])([CH3:13])[CH2:7][CH2:8][CH2:9][C:10](O)=[O:11]>O1CCCC1>[CH3:5][Si:6]([CH3:14])([CH3:13])[CH2:7][CH2:8][CH2:9][CH2:10][OH:11]참가 물질
4
실험 절차
1.5 ml (11.4 mmol) of a 1 molar solution of borane dimethylsulfide was added to a cooled (0° C.) solution of 0.61 g (3.8 mmol) of 4-(trimethylsilyl)-butanoic acid in 20 ml of dry tetrahydrofuran. After work-up using the standard procedure (methanol, tetramethylethylene diamine) and flash chromatography purification on silica gel eluted with a 9:1 mixture of hexane and ethyl acetate, 0.4 g of 4-(trimethylsilyl)-1-butanol was obtained as a colorless liquid.
후처리
- customthe standard procedure (methanol, tetramethylethylene diamine) and flash chromatography purification on silica gel
- washeluted with a 9:1 mixture of hexane and ethyl acetate
출처 및 근거
- ORD 기록
- ord-7c29f0d488274529b670e4b04765a702
- 출처 데이터셋
- uspto-grants-1993_10
- 특허 번호
- US05252587
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