2,2-Dimethoxypropane → Methyl 1,2,3,4-tetrahydronaphthalene-2-carboxylate

HRID 1656044

반응식

HRID 1656044 반응식
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[C:11]([OH:13])=[O:12].[CH3:14]OC(OC)(C)C>CO>[C:11]([CH:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:1]1)([O:13][CH3:14])=[O:12]

참가 물질

4

반응물 2

HCID 64952,2-DimethoxypropaneHCID 1013701,2,3,4-Tetrahydro-2-naphthoic acid

생성물 1

HCID 12588372Methyl 1,2,3,4-tetrahydronaphthalene-2-carboxylate

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
5 °C

실험 절차

Dissolve 1,2,3,4-tetrahydro-2-naphthoic acid (10 g, 57 mmol) in methanol (100 mL) and add dimethoxypropane (3 mL). Cool to 5° C. and saturate with hydrogen chloride gas. Allow to stand overnight then evaporate the solvent in vacuo. Take the residue up in ethyl ether, wash with saturated sodium hydrogen carbonate and dry (MgSO4). Evaporate the solvent in vacuo and distill to give 2-carbomethoxy-1,2,3,4-tetrahydronaphthalene; bp 90°-96° [email protected] mm Hg).

후처리

  1. concentrationsaturate with hydrogen chloride gas
  2. customthen evaporate the solvent in vacuo
  3. washwash with saturated sodium hydrogen carbonate
  4. dry with materialdry (MgSO4)
  5. customEvaporate the solvent in vacuo
  6. distillationdistill

출처 및 근거

ORD 기록
ord-468bb5f1f93a4377951a1538f2606c3e
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05252601

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