Ethanol → HCID 7035705, 화합물

반응식

[CH2:1](O)[CH3:2].S(=O)(=O)(O)O.[C:9]([NH:17][C@H:18]([C:22]([OH:24])=[O:23])[CH:19]([CH3:21])[CH3:20])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:9]([NH:17][C@H:18]([C:22]([O:24][CH2:1][CH3:2])=[O:23])[CH:19]([CH3:21])[CH3:20])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

반응물 3

HCID 702Ethanol

HCID 1118Sulfuric Acid

HCID 730290(2S)-3-methyl-2-(phenylformamido)butanoic acid

생성물 1

HCID 7035705HCID 7035705, 화합물수율 71%

실험 절차

Dissolve in 100 ml of ethanol 0.045 mol (10 g) of N-benzoylvaline obtained in the preceding Step, add 5 ml of concentrated sulphuric acid, then heat at reflux for 24 hours. Evaporate to dryness, take up in ether, wash with water then with a 10% potassium bicarbonate solution, dry, filter and evaporate to dryness. Ethyl N-benzoylvalinate is obtained.