2,2-Diethoxyethylamine → HCID 178467946, 화합물

HRID 1656518노트

반응식

HRID 1656518 반응식
Cl.[F:2][C:3]1[CH:13]=[CH:12][C:6]([C:7](=[NH:11])OCC)=[CH:5][CH:4]=1.[CH2:14]([O:16][CH:17]([O:20][CH2:21][CH3:22])[CH2:18][NH2:19])[CH3:15]>C(O)C>[CH2:14]([O:16][CH:17]([O:20][CH2:21][CH3:22])[CH2:18][NH:19][C:7](=[NH:11])[C:6]1[CH:5]=[CH:4][C:3]([F:2])=[CH:13][CH:12]=1)[CH3:15]

참가 물질

4

반응물 2

HCID 695242,2-DiethoxyethylamineHCID 122821594-Fluorobenzimidic acid ethyl ester hydrochloride

생성물 1

HCID 178467946HCID 178467946, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl 4-fluorobenzimidate hydrochloride (18.5 g) in ethanol (90 mL) at 0° C. was added aminoacetaldehyde diethyl acetal (14.5 mL) and the resulting solution was kept at 5° C. overnight. The solvent was evaporated, the resulting oil was dissolved in 1N sodium hydroxide (200 mL), and the solution was extracted with dichloromethane. The organic extracts were dried and evaporated to yield N-(2,2-diethoxyethyl)-4-fluorobenzamidine as an oil (21 g); MS: m/z=255(M+1).

후처리

  1. customThe solvent was evaporated
  2. dissolutionthe resulting oil was dissolved in 1N sodium hydroxide (200 mL)
  3. extractionthe solution was extracted with dichloromethane
  4. customThe organic extracts were dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-59f7e61c2cde4d8591621eb3cf94f238
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05254558

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