Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Diethyl 2-(indol-4-yloxy)malonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Diethyl bromomalonate | HCID 69637 | — |
| 반응물 | 1H-indol-4-ol | HCID 75421 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | Diethyl 2-(indol-4-yloxy)malonate | HCID 11608989 | 34% |
| 생성물 | Diethyl 2-bromo-2-(indol-4-yloxy)malonate | HCID 11639270 | 13% |
반응 단계
A solution of 4-hydroxyindole (266 mg, 2 mmol) in acetone (20 mL) was cooled to 0° C. under nitrogen and anhydrous potassium carbonate (414 mg, 3 mmol) was added. A solution of freshly distilled pure diethyl bromomalonate (574 mg, 2.4 mmol) in acetone (20 mL) was added dropwise and the mixture was stirred at room temperature overnight. Work up and flash chromatography as above afforded 7 (101 mg, 13%) and 8 (199 mg, 34%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737169B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-0c9a0cdfc8304382bf05447a70154c88 |
| 출처 메모 | uspto-grants-2010_06 |