2-Aminotetralin → N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-naphthyloxy)propanamine

HRID 1656643

반응식

HRID 1656643 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH:13]1[O:15][CH2:14]1.[NH2:16][CH:17]1[CH2:26][CH2:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18]1>C(O)C>[CH2:18]1[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:25][CH2:26][CH:17]1[NH:16][CH2:14][CH:13]([OH:15])[CH2:12][O:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1

참가 물질

4

반응물 2

HCID 346772-AminotetralinHCID 929952-Naphthyl glycidyl ether

생성물 1

HCID 19788252N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-naphthyloxy)propanamine수율 53.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1-(2-naphthyloxy)-2,3-epoxypropane (1.95 g), 2-aminotetralin (2.65 g) and ethanol (35 ml) is heated to the reflux temperature for 5 hours. The solvent is then evaporated off and the thus obtained solid residue is crystallized from ethyl acetate (5 ml), recovered by filtration, washed with ethyl acetate and then with ethyl ether, and dried yielding 1.8 g of N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-naphthyloxy)propanamine, as the free base; m.p. 102°-115° C.

후처리

  1. temperatureis heated to the reflux temperature for 5 hours
  2. customThe solvent is then evaporated off
  3. customthe thus obtained solid residue is crystallized from ethyl acetate (5 ml)
  4. filtrationrecovered by filtration
  5. washwashed with ethyl acetate
  6. dry with materialwith ethyl ether, and dried

출처 및 근거

ORD 기록
ord-6d61e845ef5d45ed9a722e30b04140de
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05254595

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