참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diethyl phenylmalonate | HCID 66514 | — |
| 반응물 | Potassium hydride | HCID 82127 | — |
| 반응물 | N-Fluorobenzenesulfonimide | HCID 588007 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Diethyl 2-fluoro-2-phenylmalonate | HCID 4246642 | 47% |
반응 단계
1 millimole of diethyl phenylmalonate was stirred with potassium hydride in 2 milliliters ether for 30 minutes at -25° C. 1.2 molar equivalents N-fluorobenzenesulfonimide prepared according to Example 1 above in 2 milliliters ether were dropped into the mixture which was stirred for 1 hour at -20° C. The mixture was allowed to warm up to room temperature and water was added. The product was extracted into ether which was dried and evaporated. Purification was carried out on a silica gel column. C6H5CF(COOCH2CH3)2 was obtained in 47% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05254732 |
|---|
| 출처 데이터셋 | uspto-grants-1993_10 |
|---|
| ORD ID | ord-89ade536182d46b086d4d518e6d9e093 |
|---|
| 출처 메모 | uspto-grants-1993_10 |
|---|
