Sulfite → 1,4,5,8-Naphthalenetetracarboxylic acid

HRID 1656858

반응식

HRID 1656858 반응식
S([O-])([O-])=O.C1C(C(N)=O)=CN(C2OC(COP(OP(OCC3OC(N4C5N=CN=C(N)C=5N=C4)C(OP([O-])([O-])=O)C3O)([O-])=O)([O-])=O)C(O)C2O)C=C1.[Na+:53].[Na+:54].[Na+].[Na+].[C:57]1([C:76]([OH:78])=[O:77])[C:66]2[C:65]([C:67]([OH:69])=[O:68])=[CH:64][CH:63]=[C:62]([C:70]([OH:72])=[O:71])[C:61]=2[C:60]([C:73]([OH:75])=[O:74])=[CH:59][CH:58]=1>>[Na:53][Na:54].[C:57]1([C:76]([OH:78])=[O:77])[C:66]2[C:65]([C:67]([OH:69])=[O:68])=[CH:64][CH:63]=[C:62]([C:70]([OH:72])=[O:71])[C:61]=2[C:60]([C:73]([OH:75])=[O:74])=[CH:59][CH:58]=1

참가 물질

5

반응물 3

HCID 1099SulfiteHCID 314221,4,5,8-Naphthalenetetracarboxylic acidHCID 12598259[2-adenin-9-yl-5-[[[[5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxymethyl]-4-hydroxy-tetrahydrofuran-3-yl] phosphate

생성물 2

HCID 314221,4,5,8-Naphthalenetetracarboxylic acidHCID 141233Disodium

실험 절차

The process as claimed in claim 6, wherein, after the oxidation has ended the reaction mixture is subjected to a heat treatment at a temperature of between 90° and 120° C. under the autogenous pressure of 1 to 10 bar which is established, in the presence of sulfite, the resulting suspension of the tetrasodium salt of naphthalene-1,4,5,8-tetracarboxylic acid is cooled, after the reaction vessel has been let down, to a temperature of below 40° C. the pH is then adjusted to 4.5 to 5 by acidification, the resulting disodium salt of naphthalene-1,4,5,8-tetracarboxylic acid is isolated, this salt is converted into the tetrasodium salt of naphthalene-1,4,5,8-tetracarboxylic acid in an aqueous alkali metal hydroxide solution and, optionally after removal of insoluble impurities, naphthalene-1,4,5,8-tetracarboxylic acid 1,8-monoanhydride is precipitated by acidification to a pH of less than 2 at a temperature of 80° to 100° C.

후처리

  1. customis subjected to a heat treatment at a temperature of between 90° and 120° C. under the autogenous pressure of 1 to 10 bar which
  2. temperatureis cooled
  3. customhas been let down, to a temperature of below 40° C.

출처 및 근거

ORD 기록
ord-fd16b247f4bd4348a18179488e19f6c6
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05254796

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